Endocrine Abstracts

Introduction: Primary hepatic neuroendocrine tumours (PHNTs) are a very rare medical entity. Usually, the liver represents the preferential site for metastasis. Large sized, singular nodules are the usual presentation of PHNTs. We report a patient with PHNTs at 4 years of tumour free follow-up.Case presentation: A 45-year-old Caucasian female who presented with nausea, vomiting, diarrhoea, accompanied by diffuse abdominal pain, was found to have on contr...

Introduction: Neurofibromatosis type 1 (NF1) is the most common type of NF, and accounts for about 90% of all cases. Primary empty sella syndrome (ESS) results from herniation of arachnoid mater into the pituitary fossa. Since it has been demonstrated that the small anterior pituitary size reflects loss of neurofibromin expression in the hypothalamus, leading to reduced GHRH, pituitary GH and IGF1 production, we agree that IGF1 and GH increased in our patient can be challengin...

Introduction: Central diabetes insipidus is a rare, chronic disease characterized by polyuria and polydipsia due to a partial or total vasopressin deficiency (hypothalamic – neurohypophysial system damage). The aetiology can be familial (autosomal dominant inheritance, X-linked recessive traits; mutation of the vasopressin – neurophysin II genes), secondary (tumours, infections, infiltrative diseases, trauma, vascular lesions) and idiopathic (10–30%).<p clas...

Introduction: Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma (MCT). Still, several physiologic and pathologic conditions other than MCT have been associated with increased levels of calcitonin, including neuroendocrine tumors that can ectopically secrete calcitonin.Case report: We present the case of a 78-year old female patient, incidentally diagnosed with multinodular goiter when performing Doppler ultrasou...

Background and Aim: Non-functioning pituitary adenomas (NFPAs) are hormonally inactive adenohypophyseal tumors. The absence of hormone hypersecretion and the lack of clinical manifestations delay the diagnosis and therefore symptoms of mass effect are frequently seen in NFPAs. The primary endpoint of this study was to evaluate the clinical presentation of patients with NFPAs and their therapeutic management. The secondary endpoint was to identify how gender and tumor size impa...

Panhypopituitarism refers to decreased production of all of the pituitary hormones of the adenohypophysis with or without deficiency of neurohypophysis function. The development of the disorder is frequently insidious and the manifestations often depend on the etiology of the condition.Case report: In October 2019 a 57-year-old man collapsed in front of the hospital after being discharged from the cardiology clinic. The day before, he had undergone angio...

Aim: To test the hypothesis that exposure to insulin glargine might be associated with increased risk of cancer mortality compared with human basal insulin preparations.Materials and methods: All consecutive diabetes patients aged over 40 years, residing in a major urban area were screened at their first diabetes outpatient visit between 01/01/2001 and 12/31/2008 (n=79 869). Exclusion criteria were insulin treatment at screening (n=14 7...

Introduction: Adiponectin is an adipocyte-derived hormone with an important role in regulation of glucose and lipid metabolism. Its variation might mediate an ameliorated metabolic profile associated with weight loss after bariatric surgery. The aim of our study was to evaluate adiponectin change as early as 6 months after laparoscopic sleeve gastrectomy (LSG) and to indicate preoperative factors that might influence its dynamic.Methods: A number of 88 e...

Objective: The aim of this study was to assess the value of some clinical and paraclinical factors in an attempt to predict outcome following antithyroid drug therapy.Methodology: We performed a retrospective audit of 101 new patients, aged 16–85, separated into two groups: 59 patients with Graves’ disease (GD) and control group of 42 patients with other ethyologic forms of hyperthyroidism, admitted to our clinic between 2003 and 2008. Data wer...

The objective of the study was to evaluate the prevalence of secreting profile among a series of subjects with incidental discovered adrenal tumors. Subjects. 139 subjects (112 women and 27 men) diagnosed with adrenal tumors between 2010 and 2015 in our department.Methods: Medical records were retrospectively analysed for demographic data, routine tests, specific adrenal hormones measurements, associated diseases.Results: Regarding...